Chemistry

Pharmacokinetics

Pharmacokinetics


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Equivalence

Another important term from pharmacokinetics is equivalence. In this context, chemical, pharmaceutical, biological and therapeutic equivalences have been defined.

Chemical equivalence refers to the equality of two drugs that contain the same amount of a therapeutically active ingredient.

Pharmaceutical equivalence means the equivalence of two medicinal products which contain the same amount of a medicinal substance in the same medicinal form, whereby here primarily the equality of different batches is to be thought of. Pharmaceutical alternatives are then preparations that contain the same therapeutic active ingredient, but not necessarily the same dosage and / or this not in the same pharmaceutical form.

Bioequivalence refers to the equivalence of two drugs with the same active ingredient, but not necessarily in the same dosage, which results in the same bioavailability if they are administered to similar subjects in the same way. According to this, both pharmaceutical products and pharmaceutical alternatives can be bioequivalent, provided that they do not reveal any significant differences in terms of bioavailability, either for single or multiple dosing.

Therapeutic equivalence refers to the equality of two drugs with the same active ingredient, which result in the same efficacy and / or toxicity if they are administered to similar test subjects in the same way.